Bryostatin down-regulates CD4 and CXCR4 receptor expression on Jurkat cells.

<p>(<b>A</b>) Jurkat cells were treated either with bryostatin (25 nM) or left untreated for 0 to 48 h followed by immunostaining with fluorescently labeled anti-CD4 and anti-CXCR4 antibodies and monitored by flowcytometry. Representative dot plots at 3 h and 48 h of bryostatin treatment, isotype control and vehicle control (DMSO). (<b>B</b>) Time course of expression profile of CD4⁺/CXCR4⁺ receptors on Jurkat cells upon treatment with bryostatin (n = 2).