Bacterial burden of <i>F. tularensis</i> within the blood, spleen, liver and lungs of infected mice.

<p>C57BL/6J mice (n = 14/group) were challenged intradermally with 10-20 CFU of <i>F. tularensis</i> A1a, A1b, A2, and type B. At time of death, organs were harvested and blood was taken from each mouse. <b>A</b>) Bacterial burden (Log₁₀ CFU/ml) within blood samples of all infection groups. No statistical difference was observed between round 1 and round 2. <b>B</b>) Bacterial burden (Log₁₀ CFU/spleen) within spleens of all infection groups. A statistical difference was observed between round 1 and round 2. <b>C</b>) Bacterial burden (Log₁₀ CFU/liver) within livers of all infection groups. No statistical difference was observed between round 1 and round 2. <b>D</b>) Bacterial burden (Log₁₀ CFU/lung) within lungs of all infection groups. A statistical difference was observed between round 1 and round 2. For all graphs, significant differences (p<0.05) in Log₁₀ CFU within round 1 infections and within round 2 infections are shown by different letters (A, B, etc.). If two strains have the same letter, no significant differences were identified between them.