<p>C57BL/6 female mice (n = 5) were infected intradermally with different strains of <i>F. tularensis</i> in 2 representative experiments. The doses given are the approximate numbers of <i>F. tularensis</i> injected (for real doses see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034639#s4" target="_blank">Materials and Methods</a>). The number of surviving mice as well as the mean time to death (MTD) and standard deviations are shown. When indicated, spleens were isolated on day 12 p.i and the numbers of CFU/ml determined. NT = not tested.</p
<p>(A) Balb/c mice (n = 10/group) were infected intradermally with the indicated number of <i>F. tul...
<p>Balb/c mice (n = 5–10/group) were infected intradermally (A) or intranasally (B) with approximate...
a<p>6–8 weeks old mice were infected i.n. with either <i>F. tularensis</i> LVS or the indicated muta...
<p>C57BL/6J mice (n = 14/group) were challenged intradermally with 10-20 CFU of <i>F. tularensis</i>...
<p>Groups of mice (•, B6; ○, B6129PF2/J; ♦, TLR2<sup>−/−</sup>; □, TLR4<sup>−/−</sup>; ▾,MyD88<sup>−...
<p>From a single challenge study, mice were exposed intranasally with Schu S4 (131 CFU), CipR mutant...
<p>C57BL/6J mice (n = 14/group) were challenged intradermally with 10-20 CFU of <i>F. tularensis</i>...
<p>C57BL/6J mice (n = 14/group; n = 7/strain) were challenged intradermally with 10–20 CFU of <i>F. ...
The type A subspecies of Francisella tularensis is a highly virulent facultative intracellular bacte...
<p>(<b>A</b>) Intracellular growth of <i>F. tularensis</i> SchuS4, ΔFTT0369c, ΔFTT1676 and ΔFTT0369c...
Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other m...
<p>Groups of 5–10 C57Bl/6 mice were intranasally infected with 50 CFU SchuS4 in 25 µl. At the indica...
<p>(A) BALB/c mice (N = 5) were anesthetized and infected with various <i>F. tularensis</i> Schu S4 ...
<p>Groups of BALB/c mice (n = 10) were challenged and survival monitored following infection by intr...
Francisella tularensis is a gram-negative facultative intracellular pathogen and the causative agent...
<p>(A) Balb/c mice (n = 10/group) were infected intradermally with the indicated number of <i>F. tul...
<p>Balb/c mice (n = 5–10/group) were infected intradermally (A) or intranasally (B) with approximate...
a<p>6–8 weeks old mice were infected i.n. with either <i>F. tularensis</i> LVS or the indicated muta...
<p>C57BL/6J mice (n = 14/group) were challenged intradermally with 10-20 CFU of <i>F. tularensis</i>...
<p>Groups of mice (•, B6; ○, B6129PF2/J; ♦, TLR2<sup>−/−</sup>; □, TLR4<sup>−/−</sup>; ▾,MyD88<sup>−...
<p>From a single challenge study, mice were exposed intranasally with Schu S4 (131 CFU), CipR mutant...
<p>C57BL/6J mice (n = 14/group) were challenged intradermally with 10-20 CFU of <i>F. tularensis</i>...
<p>C57BL/6J mice (n = 14/group; n = 7/strain) were challenged intradermally with 10–20 CFU of <i>F. ...
The type A subspecies of Francisella tularensis is a highly virulent facultative intracellular bacte...
<p>(<b>A</b>) Intracellular growth of <i>F. tularensis</i> SchuS4, ΔFTT0369c, ΔFTT1676 and ΔFTT0369c...
Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other m...
<p>Groups of 5–10 C57Bl/6 mice were intranasally infected with 50 CFU SchuS4 in 25 µl. At the indica...
<p>(A) BALB/c mice (N = 5) were anesthetized and infected with various <i>F. tularensis</i> Schu S4 ...
<p>Groups of BALB/c mice (n = 10) were challenged and survival monitored following infection by intr...
Francisella tularensis is a gram-negative facultative intracellular pathogen and the causative agent...
<p>(A) Balb/c mice (n = 10/group) were infected intradermally with the indicated number of <i>F. tul...
<p>Balb/c mice (n = 5–10/group) were infected intradermally (A) or intranasally (B) with approximate...
a<p>6–8 weeks old mice were infected i.n. with either <i>F. tularensis</i> LVS or the indicated muta...