Bacterial clearance (A) and, lung expression of chemokines (B), in <i>Klebsiella</i>-infected WT and TLR4^lps-d/TLR9^−/− mice post i.t. IL-17 treatment.

<p>WT or TLR4^lps-d/TLR9^−/− mice were challenged with 8×10² CFU <i>K. pneumoniae</i> followed immediately by intratracheal administration of 1 µg rm IL-17A or vehicle. (A) Blood and lungs were collected at 24 hours post challenge and CFU quantitated. (B) Whole lung KC/CXCL1 and MIP-2/CXCL2 levels in WT and TLR4^lps-d/TLR9^−/− mice 24 hours post treatment with <i>K. pneumoniae</i>. n = 3−5 per group. *p<0.01 and τ<0.001.