Mean plasma and brain levels of minocycline.

<p><b>Experiment 3.</b> Both plasma and brain minocycline levels were higher in WT mice compared to R6/2 mice (Plasma: F(1,19) = 1.4, p<0.01; brain: genotype main effect: F(1,10) = 19.6, p<0.002). <b>Experiment 4.</b> Brain and plasma concentrations of minocycline in R6/2 mice were significantly higher than in WT treated mice (Brain: treatment×genotype main effect: F(1,16) = 7.67, p<0.02, simple main effects: p<0.0001; plasma: genotype main effect: F(1,17) = 27.89, p<0.03) in the two 0.375% dosing groups.