Viral levels in the three compartments and activated monocytes with and w/o treatment.

<p>A. Treated animals revealed lower plasma vRNA levels (~1 log) at endpoints when compared to untreated animals at 8 wpi (cART P = 0.019; MN_persistent P = 0.0063). Lowest plasma SIV RNA levels (~2 log compared to untreated) were observed in animals that were minocycline treated and had partial immune reconstitution of the CD8⁺ T cell population (P = 0.0032). (* indicates statistically significant differences when compared to untreated animals.) B. Cerebrospinal fluid viral levels decreased in cART and in minocycline treated animals after endpoint, yet differences in cerebrospinal fluid viral burden failed to reach significance. C. Viral levels in cART and minocycline treated animals were lower than those in untreated animals (cART P = 0.007; MN_persistent P = 0.006; MN_short P< 0.0001). Short-term CD8-depleted minocycline-treated animals had significantly reduced brain vRNA levels when compared to all other cohorts, specifically in animals that were minocycline treated and CD8-depleted (P = 0.032). (* indicates statistically significant differences when compared to untreated animals. # indicates statistically significant differences when compared to all other cohorts.) D. The cART cohort and the minocycline treated cohort had significantly lower CD14⁺/CD16⁺ monocytes compared to untreated at their endpoints (cART P = 0.014; MN_persistent P = 0.004; MN_short P = 0.0035). (* indicates statistically significant differences when compared to untreated animal.).