Drug concentration in plasma and brain 2 and 24 h after SC administration of an equivalent molar dose rate of MLs in Mdr1ab(−/−) mice.

<p>Ivermectin (IVM) or moxidectin (MOX) was administered subcutaneously in Mdr1ab(−/−) mice (6 per drug) at similar molar dose rate (0.23 µmol/kg, corresponding to 0.20 mg/kg and 0.15 mg/kg for IVM and MOX, respectively). Mice were sacrificed at 2 or 24 h after treatment. Drug concentrations were determined in plasma and brain, and the brain/plasma concentration ratios were calculated.</p>*<p>p<0.05,</p>**<p>p<0.01,</p>***<p>p<0.001 <i>vs</i> IVM.