<p><i>Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multiple replicate experiments. All data are presented as absolute numerical measurements.</i></p><p>Calculated maximal responses from AR HCA.</p><p>EC50 values for Nuclear Translocation, Hyperspeckling and Total AR increase after stimulation with three AR agonists (DHT, Mibolerone and R1881) in GSF from AIS patients with AR mutations F764L, R840C and P766S. EC50 represents the nM concentration of agonist that provokes a response halfway between the baseline and maximal induction. Maximal response achieved with each agonist for each HTM parameter is expressed as % signal present in the nucleus for Nuclear Translocation, as fold-induction from t...
<p>(A) Flow cytometry of indicated Ramos transductants, showing cell number relative to DNA content ...
Primary, immortalized, or carcinoma cells were mock treated or stimulated with IFN-β or IFN-γ (100 I...
<p>FACS analysis of mCherry signals in (A) EP156T-AR-241B, (B) 957E/hTERT-AR-241B and (C) LNCaP-241B...
<p>Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multi...
<p>Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multi...
<p>Data is presented from genital skin fibroblasts cell lines obtained from AIS patients with AR mut...
<p>A, Sample of untreated or treated (with 100 nM Mibolerone) GSF images captured with the IC-100 mi...
<p>Data of fold-increase are presented from 6 genital skin fibroblasts cell lines obtained form norm...
<p>A) Number of detectable responses observed for each individual ARF peptide-pool tested. B) Number...
<p>Cells were pre-treated for 2 hours with increasing concentrations of BMS-345541 before TNFα stimu...
<p>Dotted lines indicate mean fold change values for growth factor stimulation (i.e. EGF/HGF/IGF1). ...
<p>(A) The average nuclear translocation response graphs for negative controls siCASP8, siCntrl#1, t...
<p>The frequency of the event in sensitive vs resistant lines is represented by a ratio (freq S/freq...
<p><sup>a</sup> Hmax is the maximum OD reached when the curve is saturated.</p><p><sup>b</sup>C50 re...
<p>COS-7 cells were cotransfected with GRE<sub>2</sub>-TATA-Luc reporter plasmid and pSVARo encoding...
<p>(A) Flow cytometry of indicated Ramos transductants, showing cell number relative to DNA content ...
Primary, immortalized, or carcinoma cells were mock treated or stimulated with IFN-β or IFN-γ (100 I...
<p>FACS analysis of mCherry signals in (A) EP156T-AR-241B, (B) 957E/hTERT-AR-241B and (C) LNCaP-241B...
<p>Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multi...
<p>Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multi...
<p>Data is presented from genital skin fibroblasts cell lines obtained from AIS patients with AR mut...
<p>A, Sample of untreated or treated (with 100 nM Mibolerone) GSF images captured with the IC-100 mi...
<p>Data of fold-increase are presented from 6 genital skin fibroblasts cell lines obtained form norm...
<p>A) Number of detectable responses observed for each individual ARF peptide-pool tested. B) Number...
<p>Cells were pre-treated for 2 hours with increasing concentrations of BMS-345541 before TNFα stimu...
<p>Dotted lines indicate mean fold change values for growth factor stimulation (i.e. EGF/HGF/IGF1). ...
<p>(A) The average nuclear translocation response graphs for negative controls siCASP8, siCntrl#1, t...
<p>The frequency of the event in sensitive vs resistant lines is represented by a ratio (freq S/freq...
<p><sup>a</sup> Hmax is the maximum OD reached when the curve is saturated.</p><p><sup>b</sup>C50 re...
<p>COS-7 cells were cotransfected with GRE<sub>2</sub>-TATA-Luc reporter plasmid and pSVARo encoding...
<p>(A) Flow cytometry of indicated Ramos transductants, showing cell number relative to DNA content ...
Primary, immortalized, or carcinoma cells were mock treated or stimulated with IFN-β or IFN-γ (100 I...
<p>FACS analysis of mCherry signals in (A) EP156T-AR-241B, (B) 957E/hTERT-AR-241B and (C) LNCaP-241B...