Dose dependent effects of three AR agonists on AR nuclear translocation, nuclear hyperspeckling and total AR fold-increase.

<p>Data is presented from genital skin fibroblasts cell lines obtained from AIS patients with AR mutations AR-F764L (GSF571), AR-R840C (GSF840) and AR-P766S (GSF851). Cells were maintained in 5% SD-FBS media for 12 hr and treated with the indicated compound for 18 hr in 5%SD-FBS. Tested compounds given at logarithmic concentrations (10⁻¹⁴ to 10⁻⁵ M) include the following AR agonist: DHT (-○-), Mibolerone (-▵-), and R1881(-□-).