Dose dependent effects of three AR agonists on AR nuclear translocation, nuclear hyperspeckling and total AR.

<p>Data of fold-increase are presented from 6 genital skin fibroblasts cell lines obtained form normal individuals at the time of circumcision. Cells were maintained in 5% SD-FBS media for 12 hr and treated with the indicated compound for 18 hr in 5%SD-FBS. Tested compounds given at logarithmic concentrations (10⁻¹⁴ to 10⁻⁵ M) include the following AR agonist: DHT (-○-), Mibolerone (-▵-), and R1881(-□-).