Effect of IL-6 deficiency on Kupffer cell activation during MCD diet-induced steatohepatitis.

<p>Representative pictures of immunohistochemical detection of F4/80-positive cells in the liver of WT and IL-6^−/− mice on normal (A and C) or MCD diet (B and D), respectively, are shown. Arrowheads indicate isolated Kupffer cells whereas arrows show macrophage clusters. The abundance of isolated cells and clusters was estimated in 12 and 11 livers for WT mice, and 10 and 10 for IL-6^−/− mice fed a normal or MCD diet, respectively (** p<0.01, *** p<0.001 when comparing different diets for the same genotype).