IL-6 Deficiency Attenuates Murine Diet-Induced Non-Alcoholic Steatohepatitis

The role of inflammation in the pathogenesis of non-alcoholic steatohepatitis (NASH), a common cause of liver disease, is still poorly understood. This study aimed at assessing the involvement of a major inflammatory cytokine, IL-6, in NASH. mice for 5 weeks with a methionine and choline-deficient (MCD) diet. mice.Altogether, these results indicate that IL-6 deficiency does not block the development of NASH; yet, IL-6 plays a critical role in the accompanying liver inflammation