L2 protein is the likely target of CyPB.

<p>(A) Sequence alignment of selected PV L2 proteins with CyPA binding site of HIV capsid protein. (B) 293TT cells were infected with similar amounts of HPV16 wt and 16L2-GP-N mutant pseudovirus and scored at 72 hpi. The difference in infectivity is statistically significant (p<0.01; n = 5) based on testing two independent pseudovirus preparations. (C) 16L2-GP-N mutant pseudovirus was bound to HaCaT cells in presence or absence of NIM811 for 4 h at 37°C and subsequently stained with RG-1 and K75. All images were taken with the same settings. (D) Quantification of RG-1 and K75 signal strength using randomly selected cells (n>15).