Normal follicular development in <i>Pten^loxP/loxP</i>; <i>Zp3-Cre+</i> mice.

<p>Morphological analysis of ovaries from 13- and 23-day-old, and 16-week-old <i>Pten^loxP/loxP</i>; <i>Zp3-Cre+</i> mice, <i>Pten^loxP/loxP</i>; <i>GCre+</i> mice, and control <i>Pten^loxP/loxP</i> mice. Ovaries were embedded in paraffin and sections of 8-µm thickness were prepared and stained with hematoxylin. Note the overactivation of primordial follicles in <i>Pten^loxP/loxP</i>; <i>GCre+</i> ovaries (C, F, and I, arrows) and the normal follicular development and CL in <i>Pten^loxP/loxP</i>; <i>Zp3-Cre+</i> ovaries (B, E, H and K), which is comparable to the control <i>Pten^loxP/loxP</i> ovaries (A, D, G, and J). CL, corpora lutea.