<p>The model was generated from the 3D structure of PPT and its activities against CYP3A4. PPT fitted into the model was shown in the figure. Blue represents the shape space, black represents carbon atoms, red represents oxygen atoms, and white represents hydrogen atoms.</p
<p>(A) Three-dimensional representation of the interactions of reference ligand and receptor protein...
<p>Generated pharmacophore models (A) Hypo A, (B) Hypo B and (C) Hypo C, in which hydrophobic, hydro...
<p>Superposition of three pharmacophore models Hypo A, Hypo B, and Hypo C, denoted in red, blue, and...
Starting from a set of 32 antitubercular compounds, for the first time a three-dimensional pharmacop...
Starting from a set of 32 antitubercular compounds, for the first time a three-dimensional pharmacop...
Three-dimensional pharmacophore hypothesis was built on the basis of a set of known cyclooxygenase i...
<p>Color coding of pharmacophoric features: green, hydrophobic site; magenta, acceptor site; cyan, d...
<p>The pharmacophoric features derived from the ligands are rendered as dotted spheres and are color...
<p>The key pharmacophoric features generated from the binding modes of (A) C1 and (B) Ang I. The ami...
<p>Pharmacophore models (A) Hypo A, (B) Hypo B, and (C) Hypo C fitted to <b>22</b> and (D) overlay o...
<p>Generated pharmacophore models (A) Hypo A, (B) Hypo B, and (C) Hypo C, consisting of hydrogen-bon...
<p>The pharmacophore model generated from the binding modes of (A) C15 and (B) LTA4. The amino acid ...
<p>(A) Hit1 (B) Hit2 (C) Hit3 (D) Hit4. HBA, HBD, and HYP features are displayed in green, magenta, ...
<p>The pharmacophore consists of hydrophobic features (green spheres) and a hydrogen donor feature (...
A detection of the three-dimensional binding mode between a protein and a chemical compound is valua...
<p>(A) Three-dimensional representation of the interactions of reference ligand and receptor protein...
<p>Generated pharmacophore models (A) Hypo A, (B) Hypo B and (C) Hypo C, in which hydrophobic, hydro...
<p>Superposition of three pharmacophore models Hypo A, Hypo B, and Hypo C, denoted in red, blue, and...
Starting from a set of 32 antitubercular compounds, for the first time a three-dimensional pharmacop...
Starting from a set of 32 antitubercular compounds, for the first time a three-dimensional pharmacop...
Three-dimensional pharmacophore hypothesis was built on the basis of a set of known cyclooxygenase i...
<p>Color coding of pharmacophoric features: green, hydrophobic site; magenta, acceptor site; cyan, d...
<p>The pharmacophoric features derived from the ligands are rendered as dotted spheres and are color...
<p>The key pharmacophoric features generated from the binding modes of (A) C1 and (B) Ang I. The ami...
<p>Pharmacophore models (A) Hypo A, (B) Hypo B, and (C) Hypo C fitted to <b>22</b> and (D) overlay o...
<p>Generated pharmacophore models (A) Hypo A, (B) Hypo B, and (C) Hypo C, consisting of hydrogen-bon...
<p>The pharmacophore model generated from the binding modes of (A) C15 and (B) LTA4. The amino acid ...
<p>(A) Hit1 (B) Hit2 (C) Hit3 (D) Hit4. HBA, HBD, and HYP features are displayed in green, magenta, ...
<p>The pharmacophore consists of hydrophobic features (green spheres) and a hydrogen donor feature (...
A detection of the three-dimensional binding mode between a protein and a chemical compound is valua...
<p>(A) Three-dimensional representation of the interactions of reference ligand and receptor protein...
<p>Generated pharmacophore models (A) Hypo A, (B) Hypo B and (C) Hypo C, in which hydrophobic, hydro...
<p>Superposition of three pharmacophore models Hypo A, Hypo B, and Hypo C, denoted in red, blue, and...