Development of hybrid pharmacophore models.

<p>The pharmacophore model generated from the binding modes of (A) C15 and (B) LTA4. The amino acid residues of the enzyme are shown in gray thin stick form whereas the bound C15 and LTA4 are shown in thick stick form. The secondary structure cartoon of the protein is colored based on the hydrophobicity of the amino acid residues. (C) Pharm-A (D) Pharm-B, the final hybrid pharmacophore models.