Global Gene Expression Analysis of HCV-Infected Mice

<p>Two-dimensional hierarchical clustering was done using Resolver System software with an agglomerative algorithm, average link heuristic criteria, and Cosine correlation metric. Each column represents gene expression data from an individual experiment (either individual HCV-infected mouse or individual liver sample) and the cluster represents genes that showed a greater than 2-fold change (<i>p</i> <0.05) in at least two experiments. Genes shown in red were up-regulated, genes shown in green were down-regulated, and genes shown in black indicate no change in expression in HCV-infected tissue relative to donor-matched uninfected tissue. Experiments using separate liver pieces from the same HCV-infected mouse used the same uninfected sample as the reference.