Comparative genomic analysis of human and mouse model HCC.

<p>(A) Frequency plots of copy number alterations in human HCC. Frequency of gains (red) and losses (green) as determined by ROMA array CGH analysis of 101 human HCC samples. (B) Frequency plots of copy number alterations in mouse model HCC as determined by ROMA array CGH analysis in 38 mouse model HCC samples. (C) Unsupervised hierarchical clustering of expression profiles of various mouse HCC tumors and normal stages of liver development. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0118480#pone.0118480.s008" target="_blank">S3 Table</a> for a description of the different samples.