Reduced Intracellular Fitness of Mutants That Failed to Arrest Phagosome Acidification

<p>Mutants that failed to inhibit the acidification of their phagosomes were assessed for survival over 6 d in J774 macrophages. BCGPasteur (solid squares), Tn::Rv3707c (open squares), Tn::<i>PPE10</i> (closed circles), Tn::<i>cut2</i> (solid triangles), Tn::<i>glyA1</i> (open circles). Error bars indicate ± 1 SD.