Identification of Spurious Genes

<div><p>Assessing criteria that identify candidate spurious genes in <i>S. cerevisiae,</i> using a reference set of known spurious genes [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0010001#pgen-0010001-b16" target="_blank">16</a>].</p> <p>(A) For every gene in <i>S. cerevisiae,</i> the average Pearson correlation coefficient with all other genes was calculated. Shown are histograms of the correlations associated with genes characterized as spurious in the reading frame conservation test ([<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0010001#pgen-0010001-b16" target="_blank">16</a>]; red) and all genes in the genome (black).</p> <p>(B) The distribution of gene lengths is shown for genes characterized as spurious (red) and for all genes of the genome (black).</p> <p>(C) Assessing the likelihood of being spurious as a function of gene length and correlation score. Shown is the proportion of spurious genes out of all genes whose length and correlation score fall into each of the intervals. The proportion is color-coded according to the color bar shown. <i>S. cerevisiae</i> genes with an ortholog in <i>C. albicans</i> were excluded from the analysis.</p>