ΔArm Functions through Endogenous Arm

<div><p>(A) Embryonic cuticle of <i>arm^F1a</i> mutant showing a weak loss-of-function phenotype.</p> <p>(B) Cuticle of <i>arm^LM134</i> mutant embryo showing a strong loss-of-signaling phenotype.</p> <p>(C) Embryo mutant for <i>arm^F1a</i> expressing Arm^ΔArm showing relatively normal segment polarity.</p> <p>(D) <i>arm^LM134</i> mutant expressing Arm^ΔArm also shows segment polarity.</p> <p>(E and F) Both alleles in combination with a null <i>zw3</i> allele and expressing Arm^ΔArm show a complete lack of denticles.</p> <p>(G and H) Both alleles expressing the activated but nontethered form of stabilized Arm, Arm^S10, show the naked cuticle phenotype.</p> <p>(I–L) In both missense alleles, the mutant protein is expressed in stripes (I and J), corresponding with Wg expression (data not shown), which is abolished when the key degradation kinase Zw3 is removed (K and L).</p>