Retinal vascular dysfunction in sGCα₁^−/− mice. A

<p>: Representative trace depicting the diameter in one segment of a retinal arteriole in a wild-type (WT) mouse before, during (arrow), and after injection of the NO-donor compound sodium nitroprusside. Dashed lines indicate the diameter before and after sodium nitroprusside injection. <b>B</b>: Quantitative analysis of the change in diameter (double arrow in fig. 6A) induced by injection of 0.8 mg/kg sodium nitroprusside in WT and sGCα₁^−/− mice. <i>n</i> = 5 mice (3–4 arterioles per mouse were assessed, see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060156#pone.0060156.s003" target="_blank">fig. S3</a>). *<i>P</i> = 4.1×10⁻³.