Amelioration of ischemia-induced retinal NV in the <i>β-catenin</i> KO mice with OIR.

<p>(<b>A–E</b>) Representative fluorescein angiographs of the <i>β-catenin</i> KO (KO) (<b>A, B</b>) and WT (<b>C, D</b>) mice at age P17. Red arrows in <b>A</b> and <b>C</b> indicate NV areas. Blue areas in (<b>B, D</b>) indicate vaso-obliteration (VO) regions in the central retina that was used in the quantification. (<b>E</b>) Quantification of the retinal NV area in fluorescein angiographs (n = 10). (<b>F</b>) Quantification of the VO area (n = 10). (<b>G, H</b>) Visualization of NV turfs by retina trypsin digest assay. Scale bar, 50 µm. (<b>I</b>) Quantification of retinal NV turfs in the retina with trypsin digest. All values are mean±SEM (n = 5, **p<0.01).