Kinetic analysis of Citrobacter rodentium-induced colonic hyperplasia in Rac2^−/− and WT mice.

<p>Separate groups of wild-type (WT; <i>white bars</i>) and Rac2^−/− (<i>black bars</i>) mice were infected with <i>C. rodentium</i> or given vehicle control (sham) by orogastric gavage. (A-B) Pictures show representative light photomicrographs of hematoxylin and eosin stained paraffin-embedded cross-sections of colon tissue obtained at the indicated time points of infection. Scale bar 100 µm. (C) Morphometric analysis of colonic hyperplasia; data represent average crypt length. All pictures were taken at 10× original magnification. n = 4–10/group. Data are expressed as mean ± SEM and are from one of three (in <i>A</i>) or two (in <i>B</i>) independent experiments. Statistical analysis was performed using two-way ANOVA with Tukey’s post hoc test.