<p>♀ & φ = Values from simple allometry.</p><p>Φ = Values from MLP-corrected allometry.</p
<p>Values of mice and rats are expressed the group average of 3 animals at each time-point and dogs ...
<p>LC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a s...
<p>Allometric scaling was performed by fitting a linear regression model with the log of animal mass...
<p>Linear regression analysis of log- transformed apparent volume of distribution for BALB/c mice, N...
<p>Linear regression analysis of log-transformed plasma clearance for BALB/c mice, New Zealand white...
<p>Plasma pharmacokinetic estimates for BALB/c mice, New Zealand white Hra: (NZW) SPF albino rabbits...
<p>Linear regression analysis of log-transformed plasma clearance multiplied by corresponding maximu...
Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and...
To predict human pharmacokinetics such as the clearance and the plasma concentration profile of a ne...
<p>SOI, start of infusion.</p><p>IV, intravenous.</p><p>PO, per oral.</p><p>BID, twice a day.</p
Background: Human pharmacokinetics can be predicted from animal data using the principle of allometr...
<p>Plasma concentration of ST-246 after a single oral dose of 3 (chartreuse hexagons), 10 (purple sq...
<p>Concentration-time curve for C16 on dosing via oral gavage at 300 mg/kg in the mouse.</p
The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of m...
The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of m...
<p>Values of mice and rats are expressed the group average of 3 animals at each time-point and dogs ...
<p>LC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a s...
<p>Allometric scaling was performed by fitting a linear regression model with the log of animal mass...
<p>Linear regression analysis of log- transformed apparent volume of distribution for BALB/c mice, N...
<p>Linear regression analysis of log-transformed plasma clearance for BALB/c mice, New Zealand white...
<p>Plasma pharmacokinetic estimates for BALB/c mice, New Zealand white Hra: (NZW) SPF albino rabbits...
<p>Linear regression analysis of log-transformed plasma clearance multiplied by corresponding maximu...
Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and...
To predict human pharmacokinetics such as the clearance and the plasma concentration profile of a ne...
<p>SOI, start of infusion.</p><p>IV, intravenous.</p><p>PO, per oral.</p><p>BID, twice a day.</p
Background: Human pharmacokinetics can be predicted from animal data using the principle of allometr...
<p>Plasma concentration of ST-246 after a single oral dose of 3 (chartreuse hexagons), 10 (purple sq...
<p>Concentration-time curve for C16 on dosing via oral gavage at 300 mg/kg in the mouse.</p
The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of m...
The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of m...
<p>Values of mice and rats are expressed the group average of 3 animals at each time-point and dogs ...
<p>LC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a s...
<p>Allometric scaling was performed by fitting a linear regression model with the log of animal mass...