Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis
- Yohannes, S.
- Hossain, M.A.
- Kim, J.Y.
- Lee, S.J.
- Kwak, D.M.
- Suh, J.W.
- Park, S.C.
DOIAbstract
The association between physiologically dependent pharmacokinetic parameters (CLB, T1/2β, Vdss) of marbofloxacin and body weight was studied in eight animal species based on allometric equation Y = aWb, where ‘Y’ is the pharmacokinetic parameter, ‘W’ is body weight, ‘a’ is allometric coefficient (intercept) and ‘b’ is the exponent that describes relation between pharmacokinetic parameter and body weight. The body clearance of marbofloxacin has shown significant (P<0.0001) relation with size (Bwt) in various animal species. However, half-life and volume of distribution were not in association with body weight. Although half-life and volume of distribution were not in a good correlation with body weight, statistically significant association ...
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