Metabolic flux distribution in Phase 2.

<p>Rate of selected reactions that are relevant to the metabolic state of Phase 2. The lines represent the median over simulated sets of kinetics parameters and the error bars are the 90% confidence intervals. The white, grey and yellow backgrounds represent Phase 1, 2 and 3, respectively. Abbreviations: PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PEPCK, phosphoglycerate carboxykinase; C1TS, C1-tetrahydrofolate synthase, a tri-functional enzyme that processes three distinct enzymatic activities, 5,10-methylenetetrahydrofolate (mlthf) dehydrogenase, 5,10-methenyltetrahydrofolate (methf) cyclohydrolase and 10-formyltetrahydrofolate (10fthf) synthetase.