<p>Rate of selected reactions that are relevant to the metabolic state of Phase 3. The lines represent the median over simulated sets of kinetics parameters and the error bars are the 90% confidence intervals. The white, grey and yellow backgrounds represent Phase 1, 2 and 3, respectively. Abbreviations not found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063822#pone-0063822-g002" target="_blank">Figure 2:</a> PK, pyruvate kinase; PHGDH, phosphoglycerate dehydrogenase; GC, glycine cleavage complex.</p
<p>In all panels, HCR and LCR simulations are represented by blue and red lines, respectively. Simul...
<p>The simulated metabolic flux distribution under autotrophic conditions is shown (A). The values i...
<p>Grey-scale representation of the sign distribution of the flux control coefficient shown in <a hr...
<p>Rate of selected reactions that are relevant to the metabolic state of Phase 2. The lines represe...
<p>a)–d) Exchange flux as a function of the protein aggregates concentration. e) and f) Relative vol...
And glyceraldehyde 3-phosphate () molecules. Carbon maps are shown with dashed lines. Glyceraldehyde...
And glyceraldehyde 3-phosphate () molecules. Carbon maps are shown with dashed lines. Glyceraldehyde...
<p>The values outside the bracket are relative flux values normalized to glucose uptake rates as 100...
<p>Note that several reaction pairs (Rxn 1 vs. Rxn 10; Rxn 3 vs. Rxn 9; Rxn 6 vs. Rxn 8; Rxn 49 vs. ...
<p>The yellow filled cycles are intracellular metabolites; the blue filled cycles are substrates and...
<p>(a) The diagram of glycolysis and its two branching pathways used in the analysis, where dashed s...
<p>Predicted metabolic phases as a function of the concentration of protein aggregates and the energ...
<p>The glycolytic flux is defined as the sum of the fluxes producing glycerol and pyruvate. The blac...
<p>Plots along left illustrate the convergence of the model metabolite concentrations (solid lines) ...
<p>The reaction name is shown on each plot, with the reaction name in the metabolic model in bracket...
<p>In all panels, HCR and LCR simulations are represented by blue and red lines, respectively. Simul...
<p>The simulated metabolic flux distribution under autotrophic conditions is shown (A). The values i...
<p>Grey-scale representation of the sign distribution of the flux control coefficient shown in <a hr...
<p>Rate of selected reactions that are relevant to the metabolic state of Phase 2. The lines represe...
<p>a)–d) Exchange flux as a function of the protein aggregates concentration. e) and f) Relative vol...
And glyceraldehyde 3-phosphate () molecules. Carbon maps are shown with dashed lines. Glyceraldehyde...
And glyceraldehyde 3-phosphate () molecules. Carbon maps are shown with dashed lines. Glyceraldehyde...
<p>The values outside the bracket are relative flux values normalized to glucose uptake rates as 100...
<p>Note that several reaction pairs (Rxn 1 vs. Rxn 10; Rxn 3 vs. Rxn 9; Rxn 6 vs. Rxn 8; Rxn 49 vs. ...
<p>The yellow filled cycles are intracellular metabolites; the blue filled cycles are substrates and...
<p>(a) The diagram of glycolysis and its two branching pathways used in the analysis, where dashed s...
<p>Predicted metabolic phases as a function of the concentration of protein aggregates and the energ...
<p>The glycolytic flux is defined as the sum of the fluxes producing glycerol and pyruvate. The blac...
<p>Plots along left illustrate the convergence of the model metabolite concentrations (solid lines) ...
<p>The reaction name is shown on each plot, with the reaction name in the metabolic model in bracket...
<p>In all panels, HCR and LCR simulations are represented by blue and red lines, respectively. Simul...
<p>The simulated metabolic flux distribution under autotrophic conditions is shown (A). The values i...
<p>Grey-scale representation of the sign distribution of the flux control coefficient shown in <a hr...