Detailed flux distribution map in the glycolysis, gluconeogenesis and lipid metabolism pathways.

<p>Note that several reaction pairs (Rxn 1 vs. Rxn 10; Rxn 3 vs. Rxn 9; Rxn 6 vs. Rxn 8; Rxn 49 vs. Rxn 50; and Rxn 44 vs. Rxn 45) form futile cycles. Thick black lines indicate active (or dominant) reactions whereas gray lines represent inactive (i.e. flux = 0) reactions. Dashed lines depict reactions not shown in detail. Positive flux values for reversible reactions which are in the gluconeogenic pathway in the figure indicate that gluconeogenesis is active. Fluxes of irreversible reactions should be equal or greater than zero. Directions of reactions are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054825#pone-0054825-t001" target="_blank">Table 1</a>. Flux units are µmol/g liver/h. A: Sham+Fed group; B: Sham+Fasted group; C: Burn+Fed group; D: Burn+Fasted group.