GC adhesion of APP mutant and Itgb1− deficient mouse neurons to mono-specific matrices.

<p><b>A.</b> RICM of live GCs of mutant neurons (columns) on different matrices (rows). Dark areas indicate close adhesions, bright areas are wider contacts. Scale 10 µm. Note different adhesive areas of APP−/− and hAPP+ GCs on Abp, and of the Itgb1− GC on Ibp. <b>B.</b> RICM image of live GC of a neuron transfected with scrambled siRNA on Ibp [control for adjacent image (Itgb1− on Ibp)]. <b>C.</b> Cumulative close adhesion areas of GCs in different neuron*matrix combinations (means ± s.e.). <b>D.</b> Average difference of close adhesion areas from control group and the associated 95% confidence intervals for the tested neuron*matrix combinations. Negative values indicate reduced and positive values indicate increased areas. Only the values for APP−/− and hAPP+ neurons on Abp, and for Itgb1− neurons on Ibp are significantly different (red).