Cytolytic machinery but not IFN-gamma mediates protection from liver tumor colonization.

<p>(A) Perforin KO mice or wild-type B6 were injected with 3×10⁵ B16F1 i.v. and euthanized 12 days later. The difference in tumor nodules in lungs was not significant while the difference in liver nodules was highly significant (p = 0.004). (B) IFN-γ/IL-12 KO or wild-type B6 mice were injected with B16F1 i.v. and euthanized 12 days later. The differences were not significant (C) Ly49A Tg or wild-type littermate control mice were injected with B16F1 i.v. and euthanized 12 days later. The number of pulmonary tumor nodules was significantly increased in Ly49A Tg mice as compared to WT (p = 0.018). The design of the experiments was such that all groups in each panel were examined simultaneously.