Vaccination of syngeneic mice with mIFN-γ+GGTI-298 pretreated B16F10 cells induces resistance to untreated tumor growth.

<p>C57BL/6 mice were vaccinated with untreated B16F10 cells ; mIFN-γ (50 IU/mL); GGTI-298 (10 µM); or mIFN-γ (50 IU/mL) and GGTI-298 (10 µM) pretreated B16F10 cells. (<b>A</b>) One month after vaccination tumor growth was measured after s.c. injection of 1×10⁵ live B16F10 cells, by Vernier caliper every 3 days. Groups of 6 or 7 C57Bl/6 mice were tested. Data are representative of three independent experiments. (<b>B</b>) The number of tumor free mice were calculated for each kind of vaccination. Results are pooled for the three independent experiments.