NK depletion results in establishment of liver tumor nodules and increased pulmonary tumor load.

<p>B6 mice were given control Ig or PK136 on day −3 and day 0 (i.p.) followed by i.v. injection of B16 tumor on day 0. Mice were euthanized on Day 14 and tumor nodules counted; there were five mice per group. The increase in tumor nodules in the lung was significant at p = 0.019 (indicated by *). The increase in liver tumor nodules was significant at p = 0.005 (indicated by **). The design of the experiment was such that all mice groups were processed simultaneously. A visual depiction of a similar experiment is in (B) where the bottom row shows livers from NK-depleted mice.