Doublecortin immunoreactivity in the developing dentate gyrus.

<p>Representative examples of DCX positive neuroblasts in control (A, C) and MD+NIC-exposed (B, D) P14 hippocampus. Differentiating DCX-positive cell bodies of DG (A, B) and mossy fiber projections to CA3 (C, D) are more abundant in control compared to MD+NIC. Arrowheads represent a DCX+ cell body and proximal dendrite in the plane of focus. Dashed bars are cohorts of DCX+ neurons in the subventricular zone. MF, mossy fiber; GCL, granule cell layer; DH, dentate hilus; PCL, pyramidal cell layer of CA3. Bar = 20 µm for A and B, and 50 µm for C and D.