Effects of kindling and MS on interictal neuronal firing in thalamic reticular nucleus (TRN).

<p>Representative examples of recordings from each of the four groups are depicted in A with the underscored region of each upper trace expanded in the lower trace. <b>B</b> Both MS and kindling led to significant reductions in TRN neuronal firing frequency (F_(3,168) = 5.41, *p = 0.02 for MS and F_(3,168) = 8.93, **p = 0.003 for kindling), and these effects were accompanied by significant increases in the percentage of action potentials that fired in bursts (F_(3,165) = 9.24, **p = 0.002 for MS and F_(3,165) = 16.24, ***p<0.001 for kindling, panel C). Post hoc planned comparison showed that the percentage of action potentials firing in bursts were significantly more in MS kindled rats compared to EH kindled rats (F_(3,165) = 10.82, ##p = 0.001). <b>D</b> An example of a labeled TRN cell. Data are expressed as Mean ± SEM.