Effects of kindling and MS on interictal neuronal firing in hippocampus and somatosensory cortex.

<p>Neither MS nor kindling induced any effects on hippocampal pyramidal neuronal firing frequency (A), but an increase in the percentage of burst firing in this region was observed in MS rats (F_(3,74) = 10.54, **p = 0.001). Post hoc planned comparison showed that the percentage of action potentials firing in bursts were significantly more in MS kindled rats compared to EH kindled rats (F_(3,74) = 10.92, ##p = 0.001). In primary somatosensory cortical neurons, there was no significant effect of MS or kindling in <b>C</b> firing frequency or <b>D</b> percentage of action potentials firing in burst during interictal period. Data are expressed as Mean ± SEM.