Electroretinogram response to light under scotopic conditions in wild-type and <i>Cfh</i>^−/− mice.

<p>Electrophysiological assessment of retinal function by electroretinogram (ERG) was performed on one year old <i>Cfh^−/−</i> and wild-type mice. Dark-adapted mice were used to assess scotopic neural retinal responses. Representative ERG traces (A and B) in response to flash stimuli of increasing log intensity. Mean amplitude of a-wave (C) and b-wave (D) measured from wild-type (blue line) and <i>Cfh</i>^−/− (red line) mice. Time to peak of the a-wave (E) and b-wave (F) measured from wild-type and <i>Cfh</i>^−/− mice. WT n = 6, KO n = 5. Unpaired Student’s t-tests were applied to data, *p<0.05, **p<0.01. ANOVA showed a significant increase in time to peak of a-wave (p<0.01).