<p>Group-housed, fed, male, wild-type, CD1 mice were sacrificed at 19∶30, 23∶30, or 07∶30 and tissues were harvested and snap-frozen in liquid nitrogen. Tissue glycogen concentrations were measured in epididymal adipose tissue (EPI) (<b>A</b>), interscapular brown adipose tissue (IBAT) (<b>B</b>), and liver (<b>C</b>). Error bars are ±SEM. Statistical comparisons for each tissue were made between time points using a 2-tailed Student’s t-test. <sup>#</sup>, p<0.001. 10–30 mice were used for each time point.</p
<p>The epididymal adipose tissue was frozen in liquid nitrogen. Protein and mRNA were extracted acco...
<p>Eight-week old male hP545L GAA Tg/KO mice were administered 100 mg/kg AT2220 <i>ad libitum</i> in...
<p>(A) Representative histological images of eWAT from mouse groups. (B) Quantitation of subcutaneou...
<p>Male, wild-type, CD1 mice were fed 60% of their normal daily intake of chow once daily for 5 days...
<p>Male, wild-type, CD1 mice were starved for either 72 hr (<b>A–C</b>) or 24 hr (<b>D,E</b>) and th...
<p>Effect of a glucose-rich diet on gene expression in liver (A) and adipose tissue (C). Transgenic ...
<p>IBAT was excised and snap-frozen from 8-week old mice either <i>ad libitum</i> chow-fed (Fed), 24...
<p>Cytokine protein levels measured in eWAT lysates from WT (black bars) and 12/15LO KO (gray bars) ...
<p>Mice were sacrificed at 25 and 35 weeks of age and discrete fat pads from five anatomical sites w...
<p>Male, wild-type, CD1 mice were either fed ad libitum (<b>A</b>, <b>E</b>), fed 60% of their norma...
<p>Triglyceride levels were measured in extracts from the gastrocnemius muscle, liver and white adip...
<p>Top: Biochemical analysis of glycogen content in muscle tissue of 29-week female Fzt:DU (n = 6) a...
<p>Values are presented as group mean ± SEM. WT mice n = 8, <i>Fxr</i> KO mice n = 8. Statistical an...
<p>(A) Fasting blood glucose levels were significantly higher in chow-fed C57Bl/6 mice compared with...
<p>All data are collected from 30 weeks old mice. *indicate significant p-values between <i>Lep<sup>...
<p>The epididymal adipose tissue was frozen in liquid nitrogen. Protein and mRNA were extracted acco...
<p>Eight-week old male hP545L GAA Tg/KO mice were administered 100 mg/kg AT2220 <i>ad libitum</i> in...
<p>(A) Representative histological images of eWAT from mouse groups. (B) Quantitation of subcutaneou...
<p>Male, wild-type, CD1 mice were fed 60% of their normal daily intake of chow once daily for 5 days...
<p>Male, wild-type, CD1 mice were starved for either 72 hr (<b>A–C</b>) or 24 hr (<b>D,E</b>) and th...
<p>Effect of a glucose-rich diet on gene expression in liver (A) and adipose tissue (C). Transgenic ...
<p>IBAT was excised and snap-frozen from 8-week old mice either <i>ad libitum</i> chow-fed (Fed), 24...
<p>Cytokine protein levels measured in eWAT lysates from WT (black bars) and 12/15LO KO (gray bars) ...
<p>Mice were sacrificed at 25 and 35 weeks of age and discrete fat pads from five anatomical sites w...
<p>Male, wild-type, CD1 mice were either fed ad libitum (<b>A</b>, <b>E</b>), fed 60% of their norma...
<p>Triglyceride levels were measured in extracts from the gastrocnemius muscle, liver and white adip...
<p>Top: Biochemical analysis of glycogen content in muscle tissue of 29-week female Fzt:DU (n = 6) a...
<p>Values are presented as group mean ± SEM. WT mice n = 8, <i>Fxr</i> KO mice n = 8. Statistical an...
<p>(A) Fasting blood glucose levels were significantly higher in chow-fed C57Bl/6 mice compared with...
<p>All data are collected from 30 weeks old mice. *indicate significant p-values between <i>Lep<sup>...
<p>The epididymal adipose tissue was frozen in liquid nitrogen. Protein and mRNA were extracted acco...
<p>Eight-week old male hP545L GAA Tg/KO mice were administered 100 mg/kg AT2220 <i>ad libitum</i> in...
<p>(A) Representative histological images of eWAT from mouse groups. (B) Quantitation of subcutaneou...