Effect of lithium treatment on cerebellum metabolome.

<p>Metabolic network of wild-type and <i>Sca1^154Q/+</i> cerebellum phenotypes. <b>A.</b> Wild-type mice. <b>B.</b> SCA1 knock-in mice. Red nodes: Increased metabolite levels under Lithium treatment; blue nodes: decreased levels. Node shades indicate ANOVA significance levels, node size reflect differences in magnitude of regulation. Red lines: reactant pair relationships obtained from the KEGG reaction pair database. Yellow solid lines: chemical similarity >0.5 Tanimoto score (Tanimoto scores range between 0 to 1, where 1 reflects identical structures). Yellow broken lines: chemically closest structure at <0.5 Tanimoto scores. Green circles group significant compounds that changed only in the Wild-type genotype. Orange circles group significant compounds that changed in both genotypes.