Thermal denaturation of AGT variants studied by differential scanning calorimetry (DSC).

<p>A) Representative DSC traces obtained at 3°C/min; Lines are best-fits from a two-state irreversible denaturation model with first-order kinetics <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071963#pone.0071963-Pey1" target="_blank">[6]</a>; B) Arrhenius plots for the irreversible denaturation of AGT variants, indicating also the extrapolated rate constants at physiological temperature (intercept with the vertical dotted line). Symbols are: WT (circle), LM (triangle) and p.F152I (square). Data for holo proteins are shown as closed symbols and for apo proteins as open symbols.