ROS production is reduced by the Nox inhibitor apocynin.

<p>Merged CM-H₂DCFDA fluorescence and bright field microscopy images of 40 µm vibratome sections of retinas are presented. After 1 h of blue light exposure, irradiated explants and respective non-irradiated explants (controls) were loaded with 25 µM CM-H₂DCFDA. In some cases, explants were pretreated with 4 mM apocynin during blue light exposure. The Nox inhibitor apocynin effectively reduced the levels of ROS production in the photoreceptors. The arrowheads mark the assumed border between IS and OS. The images are representative of 3 experiments. OS: outer segments; IS: inner segments; ONL: outer nuclear.