Long-term OVX increased Ca²⁺ currents and Ca²⁺ transients, but had no effect on EC-coupling gain.

<p><b>A</b>. Voltage clamp protocol shown at top. Representative Ca²⁺ transients and Ca²⁺ currents recorded in myocytes from sham and OVX mice. <b>B</b>,<b>C</b>. Mean Ca²⁺ current densities and Ca²⁺ transients were increased by long-term OVX. <b>D</b>. The gain of SR Ca²⁺ release was similar in both groups. <b>E</b>. Diastolic Ca²⁺ levels were similar in the two groups at all voltages tested. <b>F</b>. The time course of inactivation (tau) for Ca²⁺ currents activated by a test step to 0 mV was similar in sham and OVX cells. <b>G</b>. The normalized integral of the Ca²⁺ current activated by a test step to 0 mV was larger in OVX myocytes compared to sham controls (n=14 sham and 16 OVX myocytes; *p<0.05)..