Activity-dependent potentiation of mEPSC amplitude and frequency are dissociated.

<div><p>A1-3) A representative magnocellular neuron that shows an extended mEPSC amplitude potentiation that outlasts the frequency response. A1) Voltage clamp traces taken at time points as indicated. A2) Cumulative plots showing mEPSC amplitude (left panel) and interevent interval (right panel). Late post HFS is after the frequency has recovered. A3) Time-effect plots of mEPSC amplitude (top) and frequency (bottom). Solid vertical line indicates delivery of HFS, dotted vertical line with arrows denotes time when frequency is fully recovered.</p><p>B1-3) A representative magnocellular neuron that displays an extended potentiation of mEPSC frequency that outlasts the amplitude response. B1) Voltage clamp traces taken at time points as indicated. B2) Cumulative plots of mEPSC amplitude (left panel) and interevent interval (right panel) at time points as indicated. Late post HFS is after the amplitude has recovered. B3) Time-effect plots of mEPSC amplitude (top) and frequency (bottom). Solid vertical line indicates delivery of HFS, dotted vertical line with arrows denotes time when the amplitude is fully recovered.</p><p>C) Time-effect plot of mEPSC amplitude change in response to 50 Hz, 1 sec (filled circles) or 100 Hz, 1 sec x 2 stimulation (open circles). HFS was applied at time 0.</p><p>D) Relationship between the initial degree of potentiation for amplitude and frequency (1^st min post HFS). Each symbol denotes a cell. There is no significant correlation between the two parameters.</p>