Properties of potentiated mIPSCs.

<p>(A) Averaged waveform of control and post-stimulation mIPSCs, taken from two representative example cells. Note steeper onset of the events in stimulated cell (dotted lines show linear fits to the 20–80% portion of the rising phase). (B) Decay time constants (left bars, mean±s.e.m.) are unchanged in stimulated cells while rate of rise (right bars) is significantly increased. (C) Coefficient of variance of mIPSC amplitudes is decreased after stimulation. Data taken from the first 10 min interval after application of TTX; n = 22 unstimulated cells and n = 19 cells after afferent stimulation. Boxes show mean value, 25 and 75% confidence intervals, and s.e.m., respectively. (D) Potentiation depends on quantal size. Left bars show the ∼70% increase in median amplitude when all detected mIPSCs are counted within the first 10 min after washin of TTX (p<0.05). Right bars (hatched) show the median amplitudes of the 10 largest mIPSCs from each cell. The apparent amplitude increase by ∼26% is not significant.