Post-LTP does not occlude the induction of pre-LTP.

<p><b>A</b>, Post-LTP protocol, delivered to thalamic input, resulted in potentiation of EPSP to 144 ± 13% of baseline amplitude at thirty minutes after the induction (n=5, paired <i>t</i> test, p<0.05 versus baseline) in current–clamp mode. Recording mode was switched from current-clamp to voltage-clamp at thirty minutes after post-LTP induction. After EPSCs were evoked for the baseline, they were potentiated to 159 ± 17% of new baseline amplitude at thirty minutes by pre-LTP protocol (n=5, paired <i>t</i> test, p<0.05 versus baseline). Traces: averaged EPSP before (1) and after (2) post-LTP induction. Averaged EPSC before (1) and after (2) pre-LTP induction. Scale bar: 50 pA, 20 ms for voltage-clamp mode and 5 mV, 20 ms for current-clamp mode. <b>B</b>, Histogram showing quantification of results in <b>A</b>. * p<0.05.