Treatment with CHMDAPP+IL-2 does not affect bacterial colonisation in marmoset tissues following aerosol challenge with <i>B. pseudomallei</i>.

<p>Bacterial colonisation in marmoset tissues treated with CHMDAPP and IL-2 (n = 7), and group treated with IL-2 only (n = 7). Animals received a single dose of CHMDAPP (day 0, at 2.5 mg/kg) and five doses of IL-2 (days 0, 1, 2, 3, 4 and 5, at 0.18 U×10⁶ per kg) or only received the five doses of IL-2 or received PBS only. Animals were then challenged with 77–1,081 CFU of <i>B. pseudomallei</i> strain K96423 at day 5 post onset of treatment. The graph shows bacterial colonisation measured using standard viable counting. The sham group (PBS) includes some legacy data, from previously published experiments <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074789#pone.0074789-Nelson3" target="_blank">[22]</a>. Each data point represents a reading of a single organ from a single marmoset and the line represents the population median.