CHMDAPP with IL-2 alters the phenotype of γ9⁺ T cells by increasing the frequency of CD27⁻ γ9⁺ T cells and increasing the numbers of IFN⁻γ⁺γ9⁺ T cells.

<p>Phenotype of marmoset γ9⁺ T cells after treatment with CHMDAPP and IL-2 (n = 4), compared to a sham treated group (n = 2) and group treated with IL-2 only (n = 4). Animals either received a single dose of CHMDAPP (day 0, at 2.5 mg/kg) and five doses of IL-2 (days 0, 1, 2, 3, 4 and 5, at 0.18 U×10⁶ per kg) or only received the five doses of IL-2 or received PBS only. Panel A shows the proportion of circulating γ9⁺ cells not expressing CD27. Panel B shows the number of circulating γ9⁺ cells expressing IFN-γ. Panel C shows the proportion of circulating γ9⁺ T cells that register as clustered cells. Panel D shows CD27 and IFN-γ expression data generated from the spleen at 7 days post onset of treatment. Each data point is indicative of a single reading from and animal and the lines indicate the population medians. The lines are the medians and the P values are indicative of Bonferroni's post tests comparing parameters.