Infarct volume is increased in <i>Itgal</i> knockout (KO) mice.

<p>A. Collateral number does not differ between B6 and <i>Itgal</i> KO mice. B. The posterior faces of representative 1-mm coronal sections from B6 and <i>Itgal</i> KO mice are shown. The size of the infarct in <i>Itgal</i> KO is larger than B6 mice. C. <i>Itgal</i> KO mice on the B6 background exhibit infarct volume ∼3-fold larger than that of B6 mice (15.9 vs. 4.7 mm³). ** <i>P<0.001</i>. D. Increased neuronal death in the cortical region of the brain slices from <i>Itgal</i> KO mice compared to control B6 mice 24 hr after 5.5 min OGD. E. Deficiency of <i>Itgal</i> increases neuronal cell death by ∼50% compared to B6 mice. Values represent mean ± SEM from at least 5 animals per group. ** <i>P<0.001</i>.