The expression of chemokine CCL5 is up-regulated in co-cultures of BMMSCs cells and OTSCC.
- Sirpa Salo (474911)
- Carolina Bitu (474912)
- Kalle Merkku (474913)
- Pia Nyberg (114759)
- Ibrahim O. Bello (474914)
- Jussi Vuoristo (474915)
- Meeri Sutinen (314853)
- Hannu Vähänikkilä (474916)
- Daniela E. Costea (474917)
- Joonas Kauppila (474918)
- Petri Lehenkari (123659)
- Dan Dayan (474919)
- Marilena Vered (474920)
- Juha Risteli (474921)
- Tuula Salo (114754)
Publication date
October 2013
DOIAbstract
<p>Co-culture of OTSCC cells with BMMSCs results in the high expression of chemokine CCL5 in HSC-3 and SAS cells, but not in dysplastic DOK cells (A). Function-blocking monoclonal antibody against CCL5 (Mab CCL5) slightly inhibits BMMSC enhanced invasion area, but has no effect on the invasion depth, whereas the antibody against CXCL1 does not increase the inhibitory effect in OTSCC invasion (B, C).</p
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