Signaling via CCL5/CCR5 is not critical in OTSCC invasion.
- Sirpa Salo (474911)
- Carolina Bitu (474912)
- Kalle Merkku (474913)
- Pia Nyberg (114759)
- Ibrahim O. Bello (474914)
- Jussi Vuoristo (474915)
- Meeri Sutinen (314853)
- Hannu Vähänikkilä (474916)
- Daniela E. Costea (474917)
- Joonas Kauppila (474918)
- Petri Lehenkari (123659)
- Dan Dayan (474919)
- Marilena Vered (474920)
- Juha Risteli (474921)
- Tuula Salo (114754)
Publication date
October 2013
DOIAbstract
<p>The CCL5 receptor CCR5 is expressed in HSC-3 and SAS cells, but not in BMMSCs (A). rCCL5 can induce the expression of MMP9 in HSC-3 and SAS, but not in DOK cells (B). The silencing of the expression of CCR5 receptor in HSC-3 cells downregulates the gene expression about 70 % compared to control cells and blocks the signaling increasing the expression of MMP9 in cancer cells (C, D). CCR5 knockdown have minor or no effect on BMMSC enhanced invasion of HSC-3 cells in 3D organotypic model (E, F). </p
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